Resveratrol, the antioxidant found in red wine, grapes, and dark chocolate did not increase longevity or lower the risk of cancer or heart disease in a study conducted in the Italian wine country. The study, led by Richard D. Semba, MD, MPH of the Johns Hopkins University looked at older adults in the Chianti wine making region of Italy with the top dietary intake of resveratrol as indicated by its urinary metabolites. Large consumers were no more or less likely to die over the 9 year study period as small consumers or those who abstained. The actual data showed that those in the lowest consumption range did better than others as reported in the online edition of the Journal of the American Medical Association.
“Inflammatory markers, cardiovascular disease, and cancer all showed the same lack of a significant relationship with resveratrol levels. “The results were different than all of our theories” and hopes. Resveratrol had been hailed as a major component of red wine and dark chocolate and is supposed to be heart healthy. This has led to the growth of sales for it as a supplement. Sales in the USA exceed $30 million dollars per year despite no clinical evidence of its benefits. It is still promoted heavily by noted cardiologist and health televangelist Dr Oz. Derek Lowe, PhD, a drug researcher, doesn’t understand the popularity of the substance. “Personally, I do not see why anyone would take resveratrol supplements.” If it does have an effect it’s sure not a very robust or reproducible one.” The Aging in Chianti Study involved 783 men and women followed from 1998 until 2009. There was no significant difference in cardiovascular disease rates among those with the lowest levels of the drugs metabolite and those with the highest. There were no differences in the incidence of cancer between high consumers of red wine and modest to low consumers either.
While the study clearly did not show any benefit during the study period, critics of the study and its conclusion felt that maybe the benefits were more long term and required a higher dose of resveratrol over a longer period to see any real benefits. Once again I believe consuming dark chocolate and red wine in moderation is probably your best course. It is clear that a larger study with different concentrations of resveratrol over a longer period of time will be needed to reach a definitive conclusion. The study did not show that resveratrol was bad for you either. That being the case, individuals should enjoy their dark chocolate and red wine in moderate measured amounts because they enjoy dark chocolate and red wine.
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