For Arthritis of the Knee, Glucosamine and Chondroitin Sulfate is the Best Medicine to Control Long Term Symptoms of Joint Change

A paper presented at the recent American College of Rheumatology annual meeting reviewed all the research results on use of medications to control joint changes and pain in arthritic knees caused by osteoarthritis. Lucio C, Rovati, MD, of the Clinical Research Department of Rottpharm Biotech, Monza, Italy and the University of Milano Vicocca, Milano, Italy and colleagues presented the first systematic review and meta-analysis to investigate the effects of available medication used for at least a year to treat knee osteoarthritis. Their findings were published in the online journal MedPage Today. They reviewed 5992 articles discussing treatment with acetaminophen, calcitonin, celecoxib (Celebrex), chondroitin sulfate, hyaluronic acid, indomethacin, naproxen, vitamin D and zoledronic acid plus several others. The only medication that had a significant long term beneficial effect on pain and physical function was glucosamine and chondroitin sulfate. This does not mean that Tylenol, Aleve, Advil, Celebrex or other nonsteroidal anti-inflammatory drugs did not provide some immediate short term pain relief. It means that over a year they didn’t maintain the joint integrity and consistently maintain or improve function.

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