Artificial Sweeteners: Good for Weight Loss but Possible Increased Cancer Risk

J. L. Sievenpiper, MD, PhD of St. Michaels Hospital in Toronto, Canada and his associates published a review article in the Journal of the American Medical Association Network Open which looked at 17 controlled studies aimed at showing that using artificial sweeteners led to loss of weight, lower Body Mass Index (BMI) and reduction in cardiovascular risk factors. One week later, Charlotte Debras, a PhD candidate at the Sorbonne, and her colleagues published in PLoS Medicine a study showing that several of these products result in an increased risk of cancer. They noted that aspartame and acesulfame potassium carried the increased risk while sucralose did not.

Consumption of certain artificial sweeteners caused a 13% increased risk for developing obesity-related malignancies including colorectal, stomach, oral, liver, esophageal, breast, ovarian and prostate cancers. A 15% higher risk of obesity-related cancers was seen for aspartame alone and a 22% increased risk for breast cancer. They then looked at those consuming low doses of these sweeteners. They still faced a higher risk of cancers. Sucralose products did not carry a higher cancer risk at any dosage.

The message is clear. If you must consume artificial sweeteners, Sucralose is the best choice. Sucralose is used in Splenda and NutraSweet. The authors, from Paris, made it clear that they hoped a larger study of this issue would be undertaken to confirm their findings.