An Extra Tablespoon of Olive Oil Per Day May Keep Death Away

Dr. Marta Guash-Ferre’ and team at Harvard T. H. Chan School of Public Health evaluated whether substituting a teaspoon of olive oil daily to replace margarine, butter, mayonnaise and dairy fat led to a drop in the likelihood of death from cardiovascular disease, cancer, dementia and respiratory diseases.

Her team looked at 92,00 participants who were free of cancer and cardiovascular disease in 1990. Every four years, for the next 28 years of follow-up, the researchers assessed each person’s diet through a detailed questionnaire. Olive oil consumption was determined from olive oil used on salads, cooking, or used on breads and foods.

Their long-term calculations showed that olive oil consumption increased in the study participants during the test period while consumption of margarine decreased, and other fats stayed the same. Participants with higher olive oil consumption were more likely to be physically active, less likely to smoke, consumed more fruits and vegetables than lower olive oil consumers. When the researchers compared those with little olive oil consumption to those with the highest consumption, the high consumers had a 19% lower risk of death from cardiovascular disease, a 17%lower risk of cancer death, a 29% lower risk of death from dementia and an 18% lower risk of respiratory disease death. The study also concluded that substituting ten grams of olive oil per day (a bit less than one tablespoon) for other fats such as butter, margarine, mayonnaise, and dairy fat their death risk dropped by 8-34% from all causes.

In reviewing the data, its seems that their study group represented an extremely well-educated health-conscious group of individuals. Substituting olive oil for other fats is certainly a worthy goal based on these numbers and I will certainly aim to try it.

During the Pandemic: Medical Advice Is Challenged & Questioned While Patience is Thin

I, like most of the western civilized world, have had my fill of the pandemic. I see patience short both in the general population and in the medical community. The problem is that everyone seems to have lost their perspective and the value of education, experience and caring.

I received a phone call from a relatively new patient. He and his wife are recovering from breakthrough Covid-19. They are well past the point of being required to quarantine whether you use the original 14-day recommendation prior to vaccines, the revised 10-day program or the 5-day program. They still have deep, barking coughs. They do not have a fever, nor are they short of breath and they are not complaining of difficulty breathing. The cough keeps them up at night sometimes and produces clear to yellow phlegm. I advised patience, warm clear fluids, tea and honey, cough syrup and time. The patient asked for a Z-Pack (zithromycin , an antibiotic). I explained this was a viral illness not requiring an antibiotic and that the cough might be present for weeks to come. The message was poorly received.

Today as I was leaving the office the patient called back. He said that the stress of this all had stirred up his angina. He felt like he had an elephant sitting on his chest. I again asked if he was having trouble breathing and he said a bit more. He was not wheezing. He was talking comfortably on the phone. The symptoms associated with the pain did not include nausea, vomiting or massive sweating which sometimes are seen with an ongoing heart attack. The description of crushing chest pain like an elephant on the chest was sufficient to require an evaluation at a cardiac center. I suggested he sit down, take a nitroglycerin if he had one with him and call 911 immediately. He declined. He said it is probably just bronchitis and “If you don’t want to see me because of Covid issues I will just find a clinic to go to.” He told me he had heard on the news that there were no hospital beds and he didn’t want to wait for hours in an emergency room.

This patient has a history of high blood pressure, high cholesterol and had previously had a mini stroke . I explained that his complaints needed a cardiac center with heart rhythm monitoring, a quick lab to monitor cardiac enzymes and defibrillators with advanced cardiac life support trained personnel.

I called him back an hour later to see how he was feeling and what he decided to do. He was on his way to a clinic. “Must be bronchitis and if you won’t see me they will.”

As the pandemic rolls on there are no suggestions, recommendations or advice given that is not challenged and questioned. Sometimes I have to remind myself that we are on the same team, with the same goals of keeping you independent, healthy and feeling well.

I would expect with 20 plus years of schooling and training, and 40 plus years of experience and continuing education, my patients would remember we are on the same team and trust my professional experience rather than their own, or that of others, when it comes to the best interest of their health.

My interests and intent are to keep you healthy and well. However, there are medical conditions that cannot be safely seen in the office. A potential heart attack or ongoing stroke, a loss of consciousness, inability to breathe or unstoppable bleeding are a few of the conditions which require an ER not a walk-in center or physician’s office. When I suggest that a patient be seen in the emergency department I am doing so in the best interests of the patient!

I am not quite certain why when the advice is given, based on the information the patient and family provide, it is received with such skepticism?   I just know that skepticism and pushback are far greater now than they were before Covid appeared. 

I Remember When the Pharmacist Was Part of the Team

Every day I receive a phone call, email or text message from at least one of my patients saying they have been trying to refill a prescription at their local chain pharmacy for at least two weeks and they cannot get it done. The pharmacies all claim to have tried to contact “your provider” multiple times and “your provider has not responded.” 

The truth is, my staff and I have never received any of these requests from the pharmacy for a refill. Our office telephone lines are manned by human beings using no automated attendant during business hours when the office is open. After hours phone calls go directly to the physician’s cell phones. Both physicians in this office answer their cell phone calls twenty-four hours a day, seven days per week.

It is common for me to receive an email or text message after hours or on the weekend from a patient requesting a routine refill. If it is a controlled substance, I call it in myself. For nonscheduled prescription medications I will either call it in or send it by the computerized electronic health records software. If it is sent electronically, I receive a receipt for the completion of the transaction.

When I call by phone, I am commonly having to leave a detailed voice mail message because the pharmacy technicians and pharmacists are too busy to answer the phones. When the patient shows up to pick up those prescriptions, they are often told that the physician never called it in. That is usually because the pharmacy staff has not gotten around to listening to their messages on the electronic system they and/or their corporate ownership have set up. When patients are told that the doctor never called the script in, they call the office upset and annoyed that we haven’t honored their requests but, in fact, the prescription had been called in to the pharmacy hours earlier.

Years ago, the chain pharmacies decided to get into the health care business by setting up medical clinics within their pharmacies. They used their power and influence to have legislation and regulations passed to allow them to staff their clinics with nurse practitioners. At the same time, they lobbied heavily to take over and control the routine vaccination business – an important part of most primary care offices that brought patients back to the doctor periodically for a review of their health and preventive care plans.

Having clinics in pharmacies plays well with younger patients who don’t have a personal doctor and wish to perform every health evaluation and diagnosis and treatment over the screen on their smartphone. When they become significantly ill, they are left with running to emergency departments of hospitals or corporate walk-in clinics where typically a short-term solution is provided for a fee because they do not have a physician to guide them or see them.

The pharmacists I trained with were not experts on health insurance and drug benefit management programs. Those pharmacists mixed the medications and placed them in tubes, bottles or capsules. They were not just pill counters transferring pills or tablets from a stock bottle to a smaller bottle with a typed label. They were chemists and scientists. If you called them with a question, they answered your call or called you back. There was a mutual respect for the knowledge and experience they brought to the health care team that has since been lost.

The chain pharmacist is now my competitor, doing their utmost to make physicians in private practice look like inefficient, non-caring buffoons with office staff who are even less competent. There is no short-term solution to the problem.

If you contact your physician for a refill and they say they have called it in, they have done just that. If the pharmacist says the doctor never contacted them, please ask for the manager and ask if they have listened to their recorded messages or checked electronic submissions yet.

Seaweed as a COVID Treatment?

A type of sea algae known as ulna, or sea lettuce, is being tested to see if it can be used as a medication to treat SARS 2 Coronavirus. In the past, other forms of seaweed and algae have been successfully used as anti-viral agents. For this reason, researchers have tested ulna against the corona virus in lab test tubes.

They first extracted ulvan, a chemical in the sea lettuce, and then placed it in test tubes with living cells and live Coronavirus. The cells exposed to ulvan did not get infected with coronavirus. The cells only exposed to the virus did become infected. The ulvan used in this experiment came from algae grown in the lab. The native algae sea lettuce is a normal part of the diet of individuals in Japan, New Zealand and Hawaii.

The researchers used two different methods to extract the ulvan from the seaweed sea lettuce. One method produced a product that showed 10 times more anti-viral effectiveness than the other. The next step is to test this product in animals and if successful in human trials. Those experiments are being developed for further study.

After reading this article I wonder if there is any less COVID infection in the population that regularly consumes this sea lettuce and, if infected, are the clinical symptoms and presentations milder?

Disappointment in Decision-Making Regarding COVID-19

I received an email from the Chief Medical Officer at my main local hospital informing me that elective surgical and diagnostic procedures had been cancelled due to understaffing because of COVID-19 infections. He mentioned 136 employees testing positive yesterday and 36 nurses not reporting to work this morning for the day shift due to COVID. Nearby Holy Cross Medical Center has stopped delivering babies due to a shortage of staff.

I subscribe to numerous physician run newsletters that discuss expert opinions on many specialty topics. The physician writers are all at the stage of life where they and their children are young and they are grappling with in-person schooling and infection. They write about hosting large holiday gatherings and now learning that multiple attendees are ill and positive with COVID-19.

While there have been few hospitalizations so far in this young professional vaccinated group, they worry about infecting their young unvaccinated children and elderly parents with chronic illnesses. These are leaders in the health care public policy and influence pedaling industry today and their lack of discipline and ability to delay gratification has put us all in the unenviable position of having to face an absence of available medical services due to further spread of COVID-19

I have no more success with my own highly educated children who do not work in health care. My eldest child hosted a holiday gathering in Venice, California to celebrate their Christmas Canal Boat Parade and multiple attendees reported being sick four days later. She then boarded a plane to New Mexico with friends.  Upon their return, two of the three travelers are home with COVID-19

We are in a major surge of infection with a highly transmissible virus. Texas Children’s Hospital is full of children too young to be vaccinated and struggling to breathe and survive. Locally, Jack Nicklaus Children’s Hospital and Joe DiMaggio Children’s Hospital are facing similar problems.

I urge you to stay home. Wear a mask if you go out in public which is a N95 or KN95 mask or triple layer cloth surgical mask. Avoid eating out at restaurants even outside. Stay out of gyms. Stay out of country club dining rooms and card rooms. “The Board” can make those places clean but they can not make them safe from a respiratory virus with twice the transmissibility of smallpox and measles. The economy will suffer but can recover with intelligent leadership. Sadly, businesses will suffer too but they can recover. Lost children and seniors cannot be replaced.

Optimizing Disease Detection and Containment Through a Waste-Before-Case Approach

by Megan Diamond – Manager, Health Initiative, The Rockefeller Foundation & Aparna Keshaviah – Senior Statistician, Mathematica

When a new public health threat emerges – like the highly infectious Omicron variant of the SARS-CoV-2 virus – detecting the first case before there has been widespread community transmission can be like searching for the proverbial needle in a haystack.

Yet wastewater testing is a tool optimized to do just that. People infected with SARS-CoV-2 shed the virus when they go to the bathroom – including asymptomatic people who may not even know they are infected. The sewers then act like large magnets, aggregating the virus particles found in feces into centralized locations where researchers and public health officials can take samples and detect the virus, sometimes before a clinical case emerges. In fact, over the past week, multiple cities in the United States were able to detect Omicron in the wastewater before a clinical case was identified.

As vaccinations plateau and testing declines, public health officials are looking for alternative means to passively collect data that provides real-time insights for decision-making. Wastewater testing does exactly that, at the fraction of the cost of clinical testing.

Wastewater-based epidemiology (WBE) is not a new field. Decades of evidence have shown that WBE is an effective tool for detecting outbreaks of pathogens like poliovirus and typhoid, with the potential for much more. And although it has been used in several countries, including in the United States, to monitor for SARS-CoV-2, ongoing questions remain on how to best interpret and use data derived from wastewater for pandemic response.

For example, wastewater data is inherently messy, and more work is needed to reliably distinguish signal from noise in viral concentrations collected from wastewater to detect a rising threat. It’s also unclear how wastewater data should be synthesized with other local public health data—such as clinical case counts and reports of Covid-like symptoms—to provide officials with a more holistic measure of Covid-19 risk in their community. The potential of sequencing viral RNA in wastewater remains underexplored, too.

The creation of the Wastewater Action Group (WAG) – which includes leading researchers and public health officials in Atlanta (Emory University), Houston, Louisville, Tribal Nations (Arizona State University) and Tulsa  – is one of the ways that The Rockefeller Foundation and PPI are supporting cities across the US to translate wastewater data into action.  Together, this network of partners is refining wastewater sampling, testing, and sequencing protocols; developing metrics and strategies for wastewater-based risk communication; and expanding wastewater testing to underserved populations that are not connected to centralized wastewater treatment plants.

The impact of these efforts are being seen in real time:

  • In Houston, Texas, partners at the Houston Health Department and Rice University detected Omicron in the wastewater before a confirmed clinical case and subsequently sequenced positive samples from school children residing in the service areas of the wastewater treatment plan.
  • In Louisville, Kentucky, partners at the University of Louisville and Louisville Metro Dept. Public Health & Wellness detected Omicron in the wastewater before a confirmed case in Jefferson County. Through close collaboration with the State of Kentucky, they can now do targeted sequencing within the community.
  • In Tulsa, Oklahoma, partners at the Tulsa Health Department and University of Oklahoma saw an increase in influenza A virus concentration was detected in the wastewater, enabling quick communication to the public.

PPI recently met the growing need for rapid peer-to-peer learning by hosting an urgent meeting focused on wastewater sequencing in light of the emergence of Omicron. More than 30 wastewater testing leaders attended and since then, more than half have either reached out to someone they met on the call or adapted their response plans based on information shared during the session.

PPI is also dedicated to hearing from end users of public health data. Through a collaboration with Mathematica, The Rockefeller Foundation is fielding a nationwide survey among public health leaders.

The results of the survey could inform the development of decision-making tools for public health departments and help policymakers determine how they can best support wastewater surveillance across the country.

At present, no single data source provides a full picture of COVID-19. The most widely reported data—clinical case counts—overlook large swaths of the population that lack access to quality health care. As a result, the first signs of an outbreak are often detected weeks, if not months, after the emergence of a new threat. Wastewater testing is a way to fill this critical data gap.

The world can no longer wait for fragmented, delayed, and biased data. By supporting the development and scaling of wastewater-based epidemiologic tools and knowledge, PPI seeks to boost the capacity of public health officials to detect infectious disease outbreaks and prevent the next pandemic.

Omicron is the Grinch That Stole Christmas

The Center for Disease Control (CDC) is reporting that up to 90% of the infections with COVID-19 Sars 2 Coronavirus are the new Omicron strain. It replicates itself 70 times faster than the Delta strain and contact with an infected person within 12 feet for one or more seconds can result in infection. For those who have been vaccinated against COVID-19 with the Moderna or Pfizer Vaccine, and received a third shot or booster, the expectation is that if they become infected with Omicron, they will either have no symptoms or a mild case. By definition “mild COVID” means your respiratory system is not compromised enough to require hospitalization. Despite this, most of the current deaths in countries which are having a COVID surge are in people older than 65 years of age.

In the past, when patients in this area became infected with COVID-19, we arranged for them to go to the local hospitals to receive an infusion of a monoclonal antibody solution made either by Regeneron or by Eli Lilly. The infusion prevented the infection from becoming severe enough to progress to a severe state requiring inpatient hospital respiratory care. These monoclonal antibodies do not work against Omicron. For this reason, the FDA and CDC have removed the Emergency Use Authorization and ended the administration of these drugs nationwide.

There is a third monoclonal antibody made by Glaxo and Var called Sotrovimab which effectively throttles Omicron, but it is in limited supply. As of today, the State of Florida has received 1050 dosages. Production has been accelerated and hopefully the drug will be available in mid to late January for infusion. There are two new antiviral pills which should work as well. The Pfizer product received FDA approval today and, with production acceleration, some should be available by mid-January. Until these drugs are locally available the medical community has no medications to offer patients who contract the COVID-19 Delta or Omicron variant to limit the severity of the disease.

My advice to my patients and loved ones is to reintroduce distancing and masking. Wear a good N95 mask when you will be around others – especially indoors. If you must be indoors with others, make sure the windows and doors are open and the ventilation is excellent. If there is an air filtration system with HEPA Merv 13 level filters and ultraviolet light that adds protection. Distancing with the aggressive Omicron variant will require 12 feet not six feet.

This is a heartbreaking restrictive change in scheduling and behavior we are asking for at a time of the year when families and friends travel to gather to celebrate. Younger and leaner healthier individuals who are vaccinated will survive this. The real questions are who they will transmit this infection to unknowingly, who is too young to be vaccinated or too old to have a robust immune system?

Our office staff will be reassessing the risk to patients and staff daily. With the local testing positivity rate >10% in Palm Beach County, our contacts will be by phone and telehealth. When the Pfizer anti-viral pill Paxlovid is available, and or Sotrovimab for infusion, we will return to regular in-office patient visits.

I apologize for the inconvenience. Stay safe and call if you have questions.

COVID-19 & Public Health Departments

I received an email from the Florida Department of Public Health saying a Federal Judge from Missouri had struck down the necessity for health care workers to be vaccinated against COVID or risk losing their jobs. The suit was brought by several states and, while Florida was not part of this particular lawsuit, was part of other lawsuits which are ongoing.  My immediate thought is that the Florida Department of Public Health should have more important things to do such as providing public health! 

I contrast this with a story told to me by a reliable source – a 66-year-old New Yorker. He lives in the Upper West Side of Manhattan with his 63-year-old wife and spends winters at a home on the West Coast of Florida. 

They packed up their car and, for the first time, hired a professional driver to transport it plus some belongings down to their Florida winter home . They were scheduled to board a flight to Sarasota on December 2nd until the husband received a text message from the NY City Department of Health.  The message said that using cell phone location tracking data they have discovered that the husband was within six feet of an individual who tested positive for COVID-19.  They provided contact information and requested he call the number to receive precautionary recommendations.

When he called, they advised that if he was vaccinated and had no symptoms of COVID he should be tested in four to seven days but remain masked and quarantined until then. The husband stays home most days, except for a daily morning bicycle ride along the Hudson River down to Battery Park where he rents out a gym for a private 90-minute workout with a vaccinated masked trainer who is the only other individual in the facility.  He then bikes home along the Hudson River stopping at a food truck on sunny days to purchase a cup of coffee which he drinks alone on a bench overlooking the river. He and his wife mask, maintain safe distances from others and avoid indoor facilities.

The couple decided to follow the advice of the Health Department. They separated within their home staying masked indoors. They rescheduled their flights for the following week. They have appointments to have nasal PCR tests on day 7 after exposure.

Wouldn’t it be lovely if we had a public health department in Florida that actually practiced public health along with citizens who respected the health of others by following recommendations to prevent transmission of the disease?

Dementia – Multiple Trials & Interventions to Delay Cognitive Decline

There have been multiple studies presented at scientific meetings recently that look at what influences the development of dementia and what may delay it. We have known for years that anything that interferes with sensory input to the brain can lead to increased risk of dementia. Improving hearing with hearing aids was found long ago to improve your chances to avoid dementia as you age.

A recent study published by Cecelia Lee, MD MS in JAMA Internal Medicine revealed that individuals undergoing improvement of vision with cataract surgery reduced their risk of dementia significantly. The study looked at over three thousand patients undergoing cataract surgery and or glaucoma treatment between the years 1994 and September 2018. Patients were evaluated every two years during the study with Cognitive Abilities Screening Instrument (CASI) and those with scores indicating a cognitive decline were referred for more detailed testing. Although having cataract surgery reduced your risk of dementia treating glaucoma, it did not provide the same risk reduction for dementia. There were numerous theories on why cataract repair helped based on the type and quality of light reaching the retina and brain, but it was an improvement to normal in another of our senses.

Another study looked at the effect of taking a daily multivitamin on the risk of developing dementia. This study funded in part by Centrum Silver and called the COSMOS trial looked at 2262 men and women all older than sixty-five with a mean age of seventy-three. They were evaluated before entry into the study with cognitive tests and again every year for three years. Those taking a multivitamin exhibited a “slowing of cognitive aging by 60%”. Taking a multivitamin seems like an easy inexpensive intervention to preserve cognitive function and hopefully these results will be confirmed and reproduced in future studies.

Recent studies looked at the benefits in maintaining brain volume and cognitive function when drinking coffee and tea containing caffeine. The studies showed that coffee drinkers benefitted more than tea drinkers but they both benefitted in reducing the risk of cognitive decline. A recent publication took the research a step further by having test subjects drink several cups of coffee and several cups of tea per day. The benefits of drinking both beverages on the same day were far greater than drinking individually.

    Last but not least , a study executed by the Cleveland Clinic Genomic Medicine Institute under the direction of F. Cheng, PhD, looked at insurance data to determine if taking Viagra (Sildenafil) modified your risk of developing Alzheimer’s disease (one form of dementia)  The study over a 6-year period suggested that Viagra users were 69% less likely to develop Alzheimer’s disease than non-Sildenafil users. This study, which was announced and covered extensively on television news and the print media, resulted in more phone calls to my office than the other studies. This was an observational type of study and further research is needed before prescribing this medication for this preventive reason.

Of interest to me was the fact that most of the men who called asking for Viagra after reading this article were on other medications for other medical illnesses that prevented them from safely using Sildenafil products.

Phthalates and Early Death

Environmental Health is an online journal that printed the research of Leonardo Trasande, M.D. who practices and works at the NYU Grossman School of Medicine in New York City. His teams’ research found that the death toll and lost working time due to illness from phthalates were far higher than previously thought.

Their study examined middle aged adults between 55 and 64 years during the years 2013 and 2014. The analysis used the data of 5303 adults participating in the U.S. National Health and Nutrition Examination Survey who provided urine samples as part of the study. Phthalates can be measured in the urine and there are known reference ranges of normality. Their research, when extrapolated to the middle-aged population, estimates about 100,000 deaths and forty billion dollars or more lost in economic productivity among 55-64 year old Americans during 2013 and 2014.

Phthalates are a group of chemicals used to make plastics more durable. They are called “ plasticizers” and can be found in personal care products such as soaps, shampoos, hair sprays, fragrances. They are additionally seen in vinyl flooring , lubricating oils and in polyvinyl chloride plastics. These polyvinyl plastic products are seen in food wrappings, garden hoses, medical tubing ( IV tubing). Some of them get into our foods and we eat them and drink them. Some of them are aerosolized and we inhale them. In human beings we see damage to the lungs, liver, kidneys and reproductive organs from phthalate exposure.

Women apparently have a higher urinary phthalate content than men because there are so many of these chemicals in personal care products. There have even been reports of phthalates in infant diapers. Limiting exposure to these chemicals is important but learning where they are and what your risk is remains difficult. This is an area that requires far more timely research and far more transparency.